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Granulosa Cell Tumour: Causes & Treatment

July 14, 2025

Granulosa cell tumour is a slow-growing type of cancer that occurs in the cells within the ovary known as granulosa cells. The cells within the ovary assist in creating estrogen and aiding in the growth of eggs. Granulosa cell ovarian cancer is the name given to this condition, and even though it is slow-growing, it can be life-threatening if not treated.

This article is your guide for understanding Granulosa Cell Tumour, covering everything from what causes it to the symptoms to watch out for, and the best treatment options available.

What is a Granulosa Cell Tumour?

A granulosa cell tumour is a type of ovarian tumour that originates in the granulosa cells, the cells responsible for producing hormones and supporting the development of eggs within the ovaries. While not very common, this tumour can occur in women of various ages. There are two primary types:

● Adult Granulosa Cell Tumour: It is more frequent and occurs in women aged about 50 to 55 years.

● Juvenile Granulosa Cell Tumour: This is less frequent and occurs in girls and women under the age of 30.

These tumours develop in the ovaries, which are organs of a woman's reproductive system. The ovaries produce eggs and hormones such as estrogen.

Causes and Risk Factors

Physicians do not know the specific reason for granulosa cell tumours, but several things are thought to raise the risk of developing one:

● Hormone Imbalance: As these tumours produce estrogen, excessive estrogen in the body can be both a result and a cause of the tumour.

● Genetic Mutation: Alteration in a particular gene named FOXL2 is present in most instances of adult granulosa cell tumour.

● Age: This tumour primarily occurs in women at or after menopause, particularly between the ages of 50 and 55.

Also Read: Early Warning Signs of Cervical Cancer

Symptoms of Granulosa Cell Tumour

Symptoms usually result from the excess estrogen the tumour produces. Some symptoms to be aware of are:

● Unusual Bleeding: Heavy or irregular menstruation, or bleeding after menopause.

● Pain in the Belly or Pelvis: You may experience discomfort or pain in the lower area of your belly.

● Swelling or Bloating: The belly could feel full or look swollen.

● Breast Soreness: Breasts may be tender or painful.

● Early Puberty: In young girls who have juvenile tumours, the signs of puberty may begin too early.

Other health problems can also cause these symptoms, so it's crucial to visit a doctor if you observe anything abnormal.

Is Granulosa Cell Tumour Dangerous?

Yes, it might. Although granulosa cell tumours grow slowly, they may metastasise or recur even after treatment has been applied. That's why frequent checkups and early detection are crucial.

If not treated, it can lead to:

● Endometrial Hyperplasia or Cancer: Thickening of the uterine lining, which can result in cancer.

● Fertility Problem: The tumour and the extra hormones can make it difficult to conceive.

● Recurrence: Even with treatment, the tumour may recur years later.

The good news is that when diagnosed early, granulosa cell ovarian cancer has a very good survival rate.

Book an online appointment with Dr. Netra Tarun Javali for Pregnancy & Gynecology related issues.

Treatment Options

The main way to treat this tumour is through surgery. The kind of surgery depends on your age, whether you want to have children in the future, and how much the tumour has grown.

● Surgery: The doctors typically remove the tumour and, at times, the ovary. In certain instances, they can remove the two ovaries and the uterus.

● Chemotherapy: It may be required if the cancer spreads or recurs after surgery.

● Radiation: Rarely used, but may be considered in exceptional cases.

● Long-Term Monitoring: Since the tumour can recur even years later, it's essential to visit for periodic checkups.

How Cloudnine Can Help?

We offer specialised care for unusual conditions such as granulosa cell tumours at Cloudnine. Our staff comprises seasoned gynaecologic oncologists and surgeons who provide:

● Early and precise diagnosis

● Individualised surgical plans

● Chemotherapy and surveillance support

● Emotional and fertility guidance

With cutting-edge medical equipment and empathetic care, Cloudnine makes sure you don't have to face this fight alone. Whether you are fighting granulosa cell ovarian cancer or searching for answers to "Is granulosa cell tumour dangerous?" we are here to guide you every step of the way.

Conclusion

Granulosa cell tumours can be infrequent, but being aware of the symptoms, seeking early treatment, and following routine follow-ups can help manage the condition. If you or someone has symptoms or is worried about this condition, consult a healthcare expert. With proper care, such as the one available at Cloudnine, there is every reason to be optimistic and resolute.

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FAQ

Are granulosa cell tumours malignant?

Yes, they are ovarian cancers, but they develop more slowly than most cancers.

How do adults and juveniles differ?

Adult granulosa cell tumours are typically found in women nearing menopause. The juvenile variety occurs in preadolescent girls and may develop faster

What is the prognosis?

If it is found early, the chances of survival are good. Advanced or recurring tumours are more difficult to treat.

Is this a benign or malignant tumour?

It's a malignant tumour, which means it is cancer, but it tends to grow very slowly.

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