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Preimplantation Genetic Testing: Is PGS/PGT Right for You?

February 3, 2023

Pregnancy rates in women with infertility issues, especially those of advanced maternal age, are very low. IVF is one of the best options for these women, but the success rate is not that great. However, preimplantation genetic diagnosis and screening of embryos for aneuploidies can improve the success rate of IVF. But is it right for you? Find out more about this preimplantation genetic diagnosis and preimplantation genetic testing here.

What is Preimplantation Genetic Testing, PGT/PGS?

Preimplantation genetic testing is a fast-developing assisted reproductive technology done in IVF when attempting to conceive. The PGS test is a screening process that identifies the number of chromosomes in the selected embryos before IVF. There are 46 chromosomes present in a normal embryo and anything more or less is termed abnormal chromosome numbers and is called aneuploidy. If the embryo is implanted with abnormalities, it can affect conception or may have health consequences if carried for the full term. This preimplantation genetic diagnosis can be made when a couple decides to conceive through IVF. The embryos are tested for abnormalities and only those without any anomalies are implanted to increase the chances of conception and pregnancy.

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Advantages of Preimplantation Genetic Diagnosis

Now that you know the pre-implementation genetic screening definition, it is important to understand its advantages to determine if you should undergo the same. Here are some of the top benefits of the PGT test.

Better Embryo Selection

This IVF genetic testing aims to increase the chances of the selected embryo leading to a healthy and successful conception. It reduces the time taken to get pregnant, minimizes the risk of miscarriage and reduces the need for multiple embryo transfers. While the PGT test is an additional cost, this IVF genetic testing ultimately reduces the IVF treatment cost as it reduces the number of embryo transfers needed to conceive

Reduce Transmission of Unknown Genetic Abnormalities

PGS test done during the preimplantation genetic screening does not test for any particular disease. But this IVF testing looks for abnormalities in the chromosomes in terms of position and number. By making a preimplantation genetic diagnosis on viable embryos, the doctors can choose embryos with normal chromosomes and help to have a healthy birth. But for that, the preimplantation genetic screening definition should be understood, and it has to be of high quality.

Better Chances of a Successful Pregnancy

PGT test helps doctors to analyze which can be successfully implanted and develop into a healthy pregnancy. If, during the IVF genetic testing, there are abnormalities seen, it can be rejected because an abnormal chromosomal number prevents the implantation in the uterus or does not develop into a pregnancy. With the help of preimplantation genetic screening, doctors can abstain from transferring embryos. So a preimplantation genetic diagnosis helps to optimize the IVF process.

Quick Pregnancy

Using the PGT test as a preimplantation genetic diagnosis can help IVF clinics avoid the transfer of unhealthy embryos. By determining which embryos can have full-term pregnancy with preimplantation genetic screening, you don't have to spend months transferring embryos that won't result in a successful birth.

Reduces Cost

Many are of the impression that preimplantation genetic testing is an overhead cost. However, in many cases, this preimplantation genetic diagnosis is worth it. There is a payoff in the long term as only embryos suited for storage and transfer are selected. So a PGT test ensures a quicker pregnancy and reduces the need for many rounds of IVF treatments.

Less Uncertainty

Another major advantage of preimplantation genetic diagnosis is that there is lesser uncertainty among patients after the transfer of the embryo. IVF genetic testing gives you a healthy embryo and with that, there is a reduced risk of loss of pregnancy. Due to preimplantation genetic screening, there is also less emotional stress due to miscarriage.

Know the Best Plan of Action

When undergoing preimplantation genetic diagnosis, the couple should be prepared to accept the news of embryos being genetically flawed. When prepared for it, you can get into the next best option for a healthy conception and pregnancy.

Who Should Undergo Preimplantation Genetic Diagnosis?

Preimplantation genetic diagnosis is ideal for those with a family history of genetic diseases. It is also for those with a family history of disorders related to sex/gender. This test is also for:


As you can see, there are many benefits of preimplantation genetic diagnosis. It helps couples to identify birth defects and genetic disorders. However, there is a warning. There is no single test, which can predict all defects in a baby. Some develop at a later stage in childhood, others are related to toxic exposure and some are random and not based on genetics. But despite that, the PGS test is beneficial for certain IVF patients.

Must Read : An Insight Into Preimplantation Genetic Screening and Preimplantation Genetic Diagnosis


Should I do PGS Testing?

Yes. The primary purpose of preimplantation genetic testing is it helps in a healthy and successful conception. It reduces the time to become pregnant, reduces miscarriage risks, and reduces the need for multiple embryo transfers.

How accurate is PGS testing for gender?

The accuracy rate for PGS testing for gender is 100%. The fertility doctor can identify the XY and XX chromosomes with tests, which results in this accuracy.

How long does PGS testing take?

After the eggs are retrieved and allowed to develop in the laboratory. In about 3 to 5 days, cells from the embryo are biopsied and then frozen. A culture of the cells is then sent to the lab for genetic testing and analysis. This testing can take about 10 days. You can expect to get the test results in approximately 2 weeks.

Is PGS testing worth it?

Yes. PGS testing is a good choice for many IVF patients. Since it is done before the embryo transfer, it can screen for any genetic problems and thus empower couples. It can help make an informed decision based on past IVF outcomes, miscarriage history, maternal age and the IVF clinic advice.

How accurate is PGS testing for Down Syndrome?

The PGS testing for Down Syndrome is very high but not a hundred per cent. However, having said that, there is a good chance of detecting trisomy 21, which causes Down Syndrome, with PGS testing.

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