"Neural tube defect is one of the most common birth defect in the babies that is affecting the brain, the spinal tissue as well as the spinal column. That happens very early in the pregnancy, and most of the time if the pregnancy is unplanned, the woman doesn’t know that she is pregnant, we can classify the neural tube defects in two ways. The open neural tube defect or the closed neural tube defect depending on whether this neural tissue is exposed from outside or not. In open neural tube defect the most common is spina bifida. Here there is a protrusion from the lower part of the vertebral column from the lower part of the vertebral column from the defect and through that either the meninges or part of the spinal tissue can be protruded. The second most common thing is anencephaly, but this is the most severe form of neural tube defect. Here a part of the skull and the brain tissue is absent, and most of the times the babies who have anencepahy are not compatible with life. So the babies either die in utero or immediately post delivery. Third common is the encephalocele. Here a part of the brain tissue is protruded just blew the vertebra in the back of the neck. The closed neural tube defect as the name suggests is covered with a membrane or skin tissue or epithelium. Here from outside we can see a tuft of hairs, or there may be swelling over that area or sometimes there can be hemangioma or dilated blood vessels that you can see. These are the neurocutaneous markers or signatures that the baby can have. Sometimes even the gluteal fold can be abnormally placed"