Who is at risk for Neural Tube Defect?

"Neural tube defect is a multifactorial disease. So any lady who is getting pregnant or who is capable of getting pregnant, can have neural tube defect, but there are certainly some risk factors. The most important if you have a previous pregnancy which is affected with neural tube defect, then subsequent chance of neural tube defect increases. If I have one baby who is having neural tube defect then my chance will be around 5% . If I have 2 babies who is having neural tube defect, then my subsequent risk increase upto almost 10 to 20%. Right now we are having lot of lifestyle diseases like diabetes, obesity. Both of them are associated with neural tube defect. Sometimes if the mother is having some fits or seizure disorders, and if she is taking some medications, like valproic acid or carbamazepine, in the first trimester, that can also lead to neural tube defect in the baby and sometimes a simple thing like high grade fever, that can also lead to neural tube defect and the last is the ladies who are from lower socioeconomic status, mainly due to the poor nutrition, poor folic acid, they can also lead to neural tube defect in the babies"